Fenben lab fenbendazol is a popular antiparasitic drug for dogs, cats and horses. It is effective for a variety of intestinal helminth parasites including pinworms, whipworms, giardia, roundworms, hookworms, and Taenia solium. It is also used to treat pulmonary helminths (lungworms) in dogs and cats. It is a moderate-acting medication that should stop working within a few days although it may take longer in animals with liver or kidney disease.
In addition to its antiparasitic activity, fenbendazole has been shown to possess cytotoxic properties in vitro and in vivo. It acts by inhibiting the polymerization of tubulin, one of the major components that make up microtubules. The microtubules form a framework for the cell that gives it shape and allows it to move. This mechanism of action is similar to that of many cytotoxic anticancer agents, such as vinca alkaloids (vinblastine, vindexine and vinorelbine) and taxanes (paclitaxel and docetaxel).
The current article describes experiments in which fenbendazole was used in combination with radiation and docetaxel to treat EMT6 mammary tumors in BALB/c mice. The studies included both unirradiated tumors and irradiated tumors and used a rigorous colony formation assay to measure for cell viability. The results showed that intensive treatment regimens of fenbendazole reduced the viability of these tumor cells, but did not alter the dose-response curve for radiation or increase the antineoplastic effects of docetaxel.
There are several different fenbendazole formulations on the market from various companies. Some are fat soluble and require an animal to have oil in order to absorb whereas others are water soluble and can be absorbed with or without fat. The most common is Fenben Pure, which can be dissolved in an ounce or two of oil and then given to the animal to be taken orally. It contains 222 mg of fenbendazole and 778 mg of excipients. It is available in a bottle with a scoop and in pre measured capsules. fenben lab fenbendazol